Healing by second intention: wound healing by union by adhesion of granulating surfaces, when the edges of the wound are far apart and cannot be brought together. Granulations form from the base and sides of the wound toward the surface. Healing by second intention occurs when there is tissue loss, as in extensive burns and deep ulcers. The healing process is more prolonged than in healing by primary intention because large amounts of dead tissue must be removed and replaced with viable cells. |